. The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing. EMBO J. 2002 Dec 2;21(23):6367-76. PubMed.

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  1. No obvious direct link between AMPK and APPL (or APP). But it may be indirect, through membrane lipids. So, this is an in vivo model of dosing animals or cells with statins.

  2. Great article. Please see the authors comment on it at the Neurobiol Lipids noteworthy collection [ FullText
     ].