. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 2005 Aug 24;25(34):7709-17. PubMed.

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  1. It would certainly make sense if the medial temporal lobe is affected early and perhaps most agressively by AD, as the early clinical symptoms seems to suggest. Molecular studies also indicate that enzymatic activity is changed profoundly initially in both the temporal lobe and the hippocampus buried deep inside it.

    References:
    Cecil textbook of medicine... Encyclopedia of Alzheimers.

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