Sanz-Blasco S, Valero RA, Rodríguez-Crespo I, Villalobos C, Núñez L.
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
PLoS One. 2008;3(7):e2718.
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This paper describes how amyloid-β oligomers promote calcium influx, and how excessive mitochondrial Ca2+ damages the structure and function of mitochondria of Alzheimer disease neurons. The outcome of this paper may improve our basic understanding of amyloid-β oligomer toxicity, Ca2+ influx, and mitochondrial dysfunction, and may have implications for mitochondrial and calcium therapeutics for Alzheimer disease.