. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci. 2001 Mar;4(3):231-2. PubMed.

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  1. "An excellent paper, not only establishing BACE as b -secretase but also suggesting that knockout (or, by implication drug inhibition) may not have major adverse effects."