Eimer S, Lakowski B, Donhauser R, Baumeister R.
Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.
EMBO J. 2002 Nov 1;21(21):5787-96.
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So much that has been important for the understanding of APP biology has come from C elegans (and Drosophila). This paper is probably going to have a long-term importance.