Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, Watanabe M, Tomidokoro Y, Shizuka M, Mizushima K, Nakamura T, Igeta Y, Ikeda Y, Amari M, Kawarabayashi T, Ishiguro K, Harigaya Y, Wakabayashi K, Okamoto K, Hirai S, Shoji M. Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan. Ann Neurol. 1998 Jul;44(1):17-26. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ40 (CSF)
- CTRL vs AD : Aβ40 (CSF)
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ40 (CSF) |
AD (93) |
1497.5 ± 827.9 fmol/mL |
ELISA; In-house; In-house |
McKhann et al., 1984 |
| Aβ40 (CSF) |
CTRL- CNC (41) |
1361 ± 858.7 fmol/mL |
ELISA; In-house; In-house |
|
| Aβ42 (CSF) |
AD (93) |
109.9 ± 73.2 fmol/mL |
ELISA; In-house; In-house |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- CNC (41) |
241.7 ± 180.4 fmol/mL |
ELISA; In-house; In-house |
|
| tau-total (CSF) |
AD (93) |
489 ± 297.5 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- CNC (41) |
217.3 ± 128.3 pg/mL |
ELISA; Innotest; Innogenetics |
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