. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry. 2002 Jan-Feb;10(1):24-35. PubMed.

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  1. "As indicated in our paper (Shoghi-Jadid et al, 2002), we agree with Dr. Klunk's point that additional study of our new amyloid-binding agent is needed. Clearly, no single publication could have addressed all the additional areas that need to be covered. Many of the studies indicated by Dr. Klunk have either already been done (e.g., autoradiography, quantitative binding affinities for synthetic neurofibrils), or are in the process of being performed (e.g., transgenic mice determinations, tracer modeling formulation). As with any new discovery, a new set of questions emerges pointing toward further hypotheses that require testing. We appreciate Dr. Klunk's praise that our group has achieved an important milestone heralding an era of a new technology for studying amyloid deposition in living patients suffering from Alzheimer's disease. We look forward to future investigations that expand our understanding of this exciting new arena of discovery." - Jorge R. Barrio, Gary Small, both at University of California Los Angeles School of Medicine.