Offe K, Dodson SE, Shoemaker JT, Fritz JJ, Gearing M, Levey AI, Lah JJ.
The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments.
J Neurosci. 2006 Feb 1;26(5):1596-603.
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This is the latest paper in a series of studies looking at the modifying effect of LR11/SorLA on APP processing. Despite some differences to the previous paper by Andersen and coworkers, this study clearly highlights that increases in LR11/SorLA expression reduce Aβ generation. In further studies, it will be interesting to learn more about the underlying molecular mechanisms and the suitability of LR11 as a drug target.
Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE.
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6.