. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 6;414(6864):643-8. PubMed.

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  1. This careful study rigorously tests a creative concept. We have also detected BACE and APP, though not PS-1, in the same subcellular compartment in AD neurons. That APP, BACE and PS1 are colocalized at the same subcellular site in axons is intriguing and helpful to explain some important issues, but the axonal membrane compartment may not be only major site for Aβ generation (we found one or two sites in AD neurons). While sciatic nerve is a simple, good model to test this working hypothesis, it is also important to keep in mind that sciative nerve nerve cells differ from neurons in the brain, especially cortical or hippocampal neurons. The authors use corpus callosum as an axonal model, however, hippocampal or enthorinal cortex neurons may also be worth pursuing. They all contain neuronal cell bodies and their axonal projections and are pathologically affected areas in AD. This is a very good paper.

    View all comments by Yong Shen
  2. Despite intensive study the functions of APP are unknown, however an increasing number of experiments are identifying functions of APP. This paper is interesting because it identifies a function that appears to be dependent on APP which, if true, would be a major function of APP and further the understanding of its basic biology." - Benjamin Wolozin.

  3. Despite intensive study the functions of APP are unknown, however an increasing number of experiments are identifying functions of APP. This paper is interesting because it identifies a function that appears to be dependent on APP which, if true, would be a major function of APP and further the understanding of its basic biology.

    View all comments by Benjamin Wolozin
  4. This paper provided us with a new function mechanism of APP, which may give us some clues as to how to decrease amyloid peptide while not disturbing the normal function.