Michno K, Knight D, Campusano JM, Campussano JM, van de Hoef D, Boulianne GL.
Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin.
PLoS One. 2009;4(9):e6904.
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Although this is a rather blunt study in its pharmacological approach, a particularly interesting aspect of it is that a reduction in ER caclium release is observed with either wild-type or mutant presenilin 1 expression in Drosophila cholinergic neurons. This is in stark contrast to the numerous studies observing increased ER calcium responses with mutant PS expression.
The main effect of this study really appears to be that wtPS1 has the greatest effect on reducing ionomycin-evoked calcium responses, mPS1's effects being incremental. Regardless, when attempting to resolve these observations with the mechanistic studies coming from the Foskett and Bezprozvanny labs, and the observations of increased RyR-calcium responses from mine, new perspectives on the role of mutant and wt PS will hopefully emerge. Clearly, there are profound effects between PS and ER calcium, but they may not be as clear-cut or uniform across cell types/model systems as we would like them to be.