. Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium. Acta Neuropathol. 2008 May;115(5):533-46. PubMed.

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  1. I am reminded of the 1994 paper by Mirra et al. that compared neuropathological assessments of sections from AD brains and concluded "quantitative measures yielded significant differences between raters for plaque and tangle counts (p Both these studies indicate less than desirable reliability in the neuropathological assessment of AD. Might it be time to minimize reliance on the lesions described more than 100 years ago by Alzheimer and develop more reliable methods, perhaps using molecular techniques?

    See also:

    Erratum in J Neuropathol Exp Neurol 1994 Jul;53(4):425. Comment in: J Neuropathol Exp Neurol. 1995 Jan;54(1):129-31; Journal of Neuropathology & Experimental Neurology. 1994 53(3):303-15.

    References:

    . Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: a study of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). J Neuropathol Exp Neurol. 1994 May;53(3):303-15. PubMed.

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