Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM.
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.
Traffic. 2006 Jul;7(7):873-88.
Please login to recommend the paper.
To make a comment you must login or register.
This paper addresses the interesting hypothesis that Aß production may be linked to the vesicular transport of APP. The answer is apparently no, and moreover that APP and BACE1 apear to be transported in distinct vesicles.