. Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition. Brain Res. 2001 Jun 1;902(2):277-81. PubMed.

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  1. This provides histochemical evidence to support a role of the neprilysin in amyloidogenesis of AD brain. The immunoreactive intensity was not strong but favors its pathological involvement.

  2. "Neprilysin is a protease that degrades Ab and is emerging as an important regulator of Ab accumulation. The study of neprilysin represents a novel approach towards understanding Alzheimer’s pathophysiology, and understanding its biology represents a growth area for research in AD."