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Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.
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PubMed.
This could be the best model for studying AD like tauopathies, as these mice develop tangles without mutations. The finding that this only occurs when mouse tau is KO'ed is very interesting....
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Goizueta Institute @ Emory Brain Health
This could be the best model for studying AD like tauopathies, as these mice develop tangles without mutations. The finding that this only occurs when mouse tau is KO'ed is very interesting....
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