. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000 Aug;7(4):321-31. PubMed.


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  1. [I would like to note] that back in [August] 2000, we published a paper in Neurobiology of Disease (Refolo et al., 2000) demonstrating for the first time that cholesterol metabolism accelerates β-amyloid accumulation in a transgenic mouse model of AD. We show that diet-induced hypercholesterolemia alters APP processing in a manner giving rise to more A-β. What Beyreuther did was in cell lines. Our work used one of the best animals models for AD available.

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  2. This paper is most significant because it establishes that cholesterol plays a regulatory role in vivo in the pathogenesis of the AD lesions.