. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000 Aug;7(4):321-31. PubMed.

Recommends

Please login to recommend the paper.

Comments

Make a Comment

To make a comment you must login or register.

Comments on Primary Papers and News

  1. [I would like to note] that back in [August] 2000, we published a paper in Neurobiology of Disease (Refolo et al., 2000) demonstrating for the first time that cholesterol metabolism accelerates β-amyloid accumulation in a transgenic mouse model of AD. We show that diet-induced hypercholesterolemia alters APP processing in a manner giving rise to more A-β. What Beyreuther did was in cell lines. Our work used one of the best animals models for AD available.

    View all comments by Lorenzo Refolo
  2. This paper is most significant because it establishes that cholesterol plays a regulatory role in vivo in the pathogenesis of the AD lesions.