Inestrosa NC, Reyes AE, Chacón MA, Cerpa W, Villalón A, Montiel J, Merabachvili G, Aldunate R, Bozinovic F, Aboitiz F.
Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu.
Neurobiol Aging. 2005 Jul;26(7):1023-8.
Please login to recommend the paper.
To make a comment you must login or register.
This is a new model, offering a new idea about Alzheimer disease. Maybe we can use a natural pathology to understand the disease in humans.
We need more reports of the neuropathology of aging members of exotic mammalian species. Here is an example that deserves some further investigation as a model of AD. These Chilean "degus" are more closely related to guinea pigs than to lab mice or rats (Huchon and Douzery, 2001).
Huchon D, Douzery EJ.
From the Old World to the New World: a molecular chronicle of the phylogeny and biogeography of hystricognath rodents.
Mol Phylogenet Evol. 2001 Aug;20(2)