Golde TE, Janus C.
Homing in on intracellular Abeta?.
Neuron. 2005 Mar 3;45(5):639-42.
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This is a thoughtful commentary on the important paper from the UC-Irvine group, published in the same issue of Neuron, which provides evidence for an early impact of intraneural A beta upon cognition in the LaFerla triple mutant model of AD.
I agree that this is not yet the final word on the subject; important impacts of intracellular and extracellular moeities of APP-derived peptides are not mutually exclusive. Our lab, however, has favored a key role for intracellular events at least since 1993 (Fukuchi et al., 1993).
Fukuchi K, Sopher B, Martin GM.
Neurotoxicity of beta-amyloid.
Nature. 1993 Jan 14;361(6408):122-3.