Fan L, Zhao Z, Orr PT, Chambers CH, Lewis MC, Frick KM.
Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and phosphatidylinositol 3-kinase activation.
J Neurosci. 2010 Mar 24;30(12):4390-400.
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The current findings from the Frick laboratory are exciting results for those of us in the field who determined the PI3K / ERK biochemical signaling and genomic pathway induced by activating a membrane site of estrogen in the hippocampus. These findings along with earlier reports from this group constitute a strong specific link between the membrane estrogen site of action and a cognitive behavioral outcome. Further, this particular study demonstrates the critical role these membrane-associated estrogen receptors play in the cognitive phenotype in the aging female brain.