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. Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13363-7. PubMed.


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  1. The concept of AD increasing neurogenesis is extremely interesting, and the proposal that this may be a compensatory response plausible. These findings directly disprove an alternative hypothesis: that the memory deficits of AD are related to the clinical phenomenon of "chemo brain," in which patients undergoing chemotherapy and consequent probable disruption of neurogenesis exhibit memory deficits.