. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011 Feb 1;121(2):726-38. PubMed.


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  1. Wonderful, rigorous study, and perhaps a window into the future of neurodegeneration research. Though the thought is slightly disturbing, it is becoming more and more apparent that the aggregates, plaques, and tangles that we neuropathologists love to see (and preach about) may not be as important as we thought.