. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Hum Mol Genet. 2007 Jan 1;16(1):15-23. PubMed.

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  1. This is an interesting and pioneering study. It would be important to identify pathophysiological functions of DYRK1A. A similar approach may be applied to identify "bridging" molecules encoded on other chromosomes.