. Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations. J Biol Chem. 2001 Nov 16;276(46):43446-54. PubMed.

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  1. The ER appears to be a critical site for stress in neurodegenerative diseases. Several of the proteins that are implicated in neurodegenerative disease are present in the ER, and affect ER stress responses. Our understanding of the mechanism by which proteins, such as PS1, affect ER stress signaling could provide important insights into understanding the mechanism of disease.

  2. Still more confusion about the upr and presenilins. Initial defects in upr reported for presenilins not confirmed by Thinakaran lab.