. Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1381-6. PubMed.


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  1. The is an interesting and somewhat unexpected finding. At 100 days of age PDAPP mice show a small but significant decrease in hippocampal volume (12.3%). This is before there is measurable biochemical or immunohistochemical Abeta deposition. The main quesiton raised by this study is whether the change is due to APP, soluble Abeta, or even non-specific transgene effects. Further studies will be needed to sort out these possibilities.