. Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP. J Biol Chem. 2006 Sep 29;281(39):29096-104. PubMed.


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  1. It is surprising and unanticipated that a mitochondrial matrix peptidase would play a role in degrading Aβ. It begs the question of how Aβ, which is normally considered to be a secreted protein, would be mislocalized to the mitochondria matrix.