Kallop DY, Meilandt WJ, Gogineni A, Easley-Neal C, Wu T, Jubb AM, Yaylaoglu M, Shamloo M, Tessier-Lavigne M, Scearce-Levie K, Weimer RM. A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models. J Neurosci. 2014 May 7;34(19):6425-37. PubMed.

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  1. Our unpublished look at this interaction showed by SPR and NMR that recombinant DR6 associates with APP via the disordered stalk domain, rather than the globular cys-rich domain.

    View all comments by Luke A. Miles

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