. Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. J Neurosci. 2004 May 12;24(19):4535-40. PubMed.

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  1. The finding of no effect on synaptic integration prior to plaque accumulation seems at variance with other data (e.g. Redwine et al., 2003; Oddo et al., 2003 ) showing significant effects on parameters such as LTP prior to plaque accumulation in transgenic mice. May the apparent discrepancy be resolved on the basis of differences in measures of synaptic function, specific circuits examined and different animal models (at least in some cases)?

    References:

    . Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1381-6. PubMed.

    . Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31;39(3):409-21. PubMed.