. Contribution of Vascular Brain Injury and Brain Abeta to Cognitive Function. Human Amyloid Imaging Abstract. 2012 Jan 1;

Abstract:

Background: Vascular brain injury (VBI) and brain Abeta deposition frequently co-occur and both may induce cognitive decline in aging. This study evaluated the relative contribution of VBI and Abeta to cognitive function in a cognitively diverse population. Methods:1 participants (female =8, mean age =7.8), enrolled in a vascular-focused study of aging that recruits cognitively normal and impaired participants (Clinical Dementia Rating [CDR] 0: N =0; .5: N =5; >.5: N =), underwent MRI, PIB-PET imaging, and cognitive testing. MRI images were visually rated for presence and location of infarct (VBI+:4; VBI-:7). PIB-PET DVRs (Logan plotting,5-90min post-injection, grey matter cerebellar reference) were used to create a PIB index by averaging DVRs across frontal, posterior cingulate, precuneus, parietal and lateral temporal cortices. Participants with a PIB index SDs greater than the mean PIB index of a young control group (N =1, mean age =4.5 ±.5) were classified as PIB positive (PIB+: N =9; PIB-: N =2). Standardized composite tests of cognition included measures of Global cognition, Memory, and Executive Functioning.
Results: VBI, particularly when located in subcortical grey matter, was associated with lower cognitive performance in all domains (p’s Conclusions: In this sample of cognitively diverse older adults, VBI played a more influential role than Abeta in cognitive function, and remained a significant predictor of cognition after controlling for the possible influence of Abeta.

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