The concentration of soluble extracellular amyloid-β protein in acute brain slices from CRND8 mice.
PLoS One. 2010;5(12):e15709.
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Given the increasing trend of studying the biological effects of β amyloid in live tissue preparations rather than biochemically, this study is particularly relevant and eye opening. The rigorous and biophysical nature of this study shouldn't intimidate the more biologically minded, as the results and implications are clear. In experiments using brain tissue, great care is called for when interpreting data implicating β amyloid and when making comparisons between in vitro and in vivo conditions.