Landau SM, Lu M, Joshi AD, Pontecorvo M, Mintun MA, Trojanowski JQ, Shaw LM, Jagust WJ, .
Comparing PET imaging and CSF measurements of Aß.
Ann Neurol. 2013 Mar 28;
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This is an important paper which describes the temporal relationship between changes in CSF Aβ42 and in PIB-PET signals. The work implies that the latter changes precede the former. This observation is probably consistent with the presumption that Aβ plaques (fibrils) retain and adsorb soluble ISF Aβ42 like a "black hole."