. Clustering expressed genes on the basis of their association with a quantitative phenotype. Genet Res. 2005 Dec;86(3):193-207. PubMed.

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  1. This may be a useful statistical method. It deserves scrutiny from a card-carrying statistician.

  2. This paper addresses an important area that is largely unexplored in disease. For example, one could identify genes associated with a particular quantitative endophenotype by arrays and correlate with QTL mapping methods to identify differentially expressed genes that are under linkage peaks--moving quickly to candidates...