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  1. A mechanism to inhibit partially PS1 expression without modifying Notch activity has been postulated in our recent paper in FEBS Letters. It should be noted that the compound used is physiologically produced in the right amount in young people and strongly reduced in the elderly. We would like to see our paper considered in the course of this discussion.

    References:

    . Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?. FEBS Lett. 2003 Apr 24;541(1-3):145-8. PubMed.

    View all comments by Sigfrido Scarpa