. Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J Neurochem. 2006 Dec;99(6):1445-55. PubMed.

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  1. This interesting study has implications for tau-focused AD drug discovery, and with the inclusion of a lithium trial in the AD Cooperative Study, there will be human data to consider within a few years that will help us understand how to target tau for therapy of AD and related tauopathies.