. Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurol. 2010 Oct;9(10):978-85. PubMed.

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  1. I think it will be found that aquaporin 3 will be the item of interest (1).

    Aquaporin 3 is found in "normal skeletal myofibres" (2).

    I suspect it will be found that the problem is not a mutation, but something interfering with the normal proper function of the aqp3 channels.

    Aquaporin 3 is, in addition to being a water channel, also an arsenic transporter.

    Arsenic has been implicated in Alzheimer's in at least a few instances. For example, this statement appears in Reference 3 below:

    "Arsenic can induce apoptosis in cortical neurons of rats. This process is based on the activation of JNK3 and p38 MAPK by arsenic...[which] can activate p38 MAPK and JNK3...."

    And the title of the last paper speaks for itself: “Arsenic exposure may be a risk factor for Alzheimer's disease.”

    View all comments by P.F. Jennings