de Jong D, Jansen RW, Kremer BP, Verbeek MM. Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia. J Gerontol A Biol Sci Med Sci. 2006 Jul;61(7):755-8. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(61)		 419 ± 128
ng/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
Other Controls
(30)		 869 ± 207
ng/mL		 ELISA;
Innotest;
Innogenetics
Aβ42
(CSF)		 VaD
(25)		 655 ± 220
ng/mL		 ELISA;
Innotest;
Innogenetics		 Román et al., 1993
tau-p181
(CSF)		 AD
(61)		 103 ± 44
ng/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
Other Controls
(30)		 53 ± 16
ng/mL		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 VaD
(25)		 47 ± 14
ng/mL		 ELISA;
Innotest;
Innogenetics		 Román et al., 1993
tau-total
(CSF)		 AD
(61)		 613 ± 326
ng/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
Other Controls
(30)		 184 ± 89
ng/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 VaD
(25)		 303 ± 307
ng/mL		 ELISA;
Innotest;
Innogenetics		 Román et al., 1993

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AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. VaD vs AD : Aβ42 (CSF)
  4. AD vs CTRL : tau-p181 (CSF)
  5. CTRL vs AD : tau-p181 (CSF)
  6. VaD vs AD : tau-p181 (CSF)
  7. AD vs CTRL : tau-total (CSF)
  8. CTRL vs AD : tau-total (CSF)
  9. VaD vs AD : tau-total (CSF)