. Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation. J Biol Chem. 2004 May 21;279(21):21948-56. PubMed.

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  1. The approaches taken by the authors seem sound and the findings are interesting and suggestive. Synthesis of a solely calpain-specific low molecular weight inhibitor may lead to a "dream medication" that can be used to treat Alzheimer's disease, vascular dementia, Parkinson's disease, polyglutamine disease, and now prion disease. There remains, however, a very basic question regarding this particular work: How can calpains, exclusively intracytoplasmic proteins, have access to PrP, a GPI-anchored extracytoplasmic protein?

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