. Both total and phosphorylated tau are increased in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 May;70(5):624-30. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
albumin ratio
(CSF/Blood)
AD-
Possible Alzheimer's Disease
(19)
7.9 ± 2.9
mg/L:g/L
Nephelometry;
Other/Not Specified;
Other/Not Specified
McKhann et al., 1984
albumin ratio
(CSF/Blood)
AD-
Probable Alzheimer's Disease
(41)
5.4 ± 1.8
mg/L:g/L
Nephelometry;
Other/Not Specified;
Other/Not Specified
McKhann et al., 1984
albumin ratio
(CSF/Blood)
CTRL-
CNC
(17)
5.3 ± 1.8
mg/L:g/L
Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)
CTRL-
CNC
(17)
5.3 ± 1.8
mg/L:g/L
Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)
FTD
(18)
9.7 ± 2.9
mg/L:g/L
Nephelometry;
Other/Not Specified;
Other/Not Specified
1994
albumin ratio
(CSF/Blood)
PD
(15)
6.8 ± 2.4
mg/L:g/L
Nephelometry;
Other/Not Specified;
Other/Not Specified
Wallin et al., 1999
albumin ratio
(CSF/Blood)
VaD
(17)
11.9 ± 7.2
mg/L:g/L
Nephelometry;
Other/Not Specified;
Other/Not Specified
tau-p181
(CSF)
AD-
Possible Alzheimer's Disease
(19)
18.01 ± 5.86
pM
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-p181
(CSF)
AD-
Probable Alzheimer's Disease
(41)
23.1 ± 10.1
pM
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-p181
(CSF)
CTRL-
CNC
(17)
15.9 ± 5.7
pM
ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)
CTRL-
CNC
(17)
15.9 ± 5.7
pM
ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)
FTD
(18)
8.6 ± 3.9
pM
ELISA;
Innotest;
Innogenetics
1994
tau-p181
(CSF)
PD
(15)
14.1 ± 3.1
pM
ELISA;
Innotest;
Innogenetics
Wallin et al., 1999
tau-p181
(CSF)
VaD
(17)
6.4 ± 5.6
pM
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
AD-
Possible Alzheimer's Disease
(19)
16.34 ± 4.3
pM
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
AD-
Probable Alzheimer's Disease
(41)
20 ± 7.6
pM
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
CTRL-
CNC
(17)
8.3 ± 2.8
pM
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
CTRL-
CNC
(17)
8.3 ± 2.8
pM
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
FTD
(18)
9.7 ± 2.9
pM
ELISA;
Innotest;
Innogenetics
1994
tau-total
(CSF)
PD
(15)
7.5 ± 1.6
pM
ELISA;
Innotest;
Innogenetics
Wallin et al., 1999
tau-total
(CSF)
VaD
(17)
3.7 ± 2.3
pM
ELISA;
Innotest;
Innogenetics

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