Maddalena A, Papassotiropoulos A, Müller-Tillmanns B, Jung HH, Hegi T, Nitsch RM, Hock C. Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42. Arch Neurol. 2003 Sep;60(9):1202-6. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(51)		 420 ± 190
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(31)		 730 ± 220
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 AD
(51)		 52 ± 19
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(31)		 27 ± 10
pg/mL		 ELISA;
Innotest;
Innogenetics

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