Basic Principles and Controversies in PET Amyloid Imaging.
Human Amyloid Imaging Abstract. 2012 Jan 1;
The talk will focus on some of the technical issues of amyloid imaging using positron emission tomography (PET) with an emphasis on image analysis, data extraction and interpretation. With the huge increase in interest over the past decade around [11C]PiB and now several new [18F]-labeled compounds for measuring amyloid burden, there has been considerable effort by many groups in assessing not only how well these tracers work and why, but also on the optimal ways to perform analyses and extract quantitative data. This has led to a variety of issues in the field, some still being quite controversial in regard to what are the most important areas of amyloid imaging methodology and how to implement these methods. Topics covered will include: 1) choice of reference tissue -- theoretical vs. practical issues; 2) differences between [11C]PiB and [18F]florbetapir (AV-45) and how they effect choices in methodology; 4) thresholds for amyloid positivity and how these vary with radiotracer and methods; 5) considerations for longitudinal versus cross-sectional analyses, and 6) partial volume correction -- help or hindrance.