Henneman WJ, Vrenken H, Barnes J, Sluimer IC, Verwey NA, Blankenstein MA, Klein M, Fox NC, Scheltens P, Barkhof F, van der Flier WM.
Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease.
Neurology. 2009 Sep 22;73(12)
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This is an interesting paper that adds additional information about the value of multiple biomarkers as predictors of future decline in older persons. Specifically, CSF pTau predicted subsequent hippocampal atrophy independent of baseline atrophy and cognitive impairment. These data add to our knowledge about the utility of individual and combinations of biomarkers for predicting subsequent neurodegeneration.