Langbaum JB, Chen K, Liu X, Fleisher AS, Reeder S, Bandy D, Alexander GE, Caselli RJ, Reiman EM.
Association between pulse pressure and fibrillar amyloidbeta burden in cognitively normal, late middle-aged people at three levels of genetic risk for Alzheimer’s disease.
Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;
Background: Epidemiological studies suggest an association between cardiovascular disease risk factors in
mid-life and Alzheimer’s disease (AD) in late-life. In the present study we used Pittsburgh Compound-B (PiB)
positron emission tomography (PET) to examine the relationship between blood pressure (BP) measures and this
brain imaging measurement of pre-symptomatic AD in a cohort of cognitively normal, late middle-aged APOE ε4
homozygotes (HM), heterozygotes (HT) and non-carriers (NC).
Methods: Mean systolic and diastolic BP was computed from three supine measurements. SPM5 was used
to characterize relationships between systolic BP (SBP), diastolic BP (DBP) and peripheral pulse pressure (PP)
with regional-to-cerebellar PiB PET distribution volume ratios (DVR) in 32 cognitively normal persons (mean age
65.5±4.5), including 8 HM, 11 HT, and 13 NC.
Results: The APOE ε4 groups did not differ significantly in demographic characteristics, clinical ratings or
neuropsychological test scores. 19% of the participants’ BP measurements met criteria for hypertension and
34% reported using anti-hypertensive medications. SBP was positively correlated and DBP negatively correlated
with PiB DVR bilaterally in frontal, temporal and precuneus regions (pConclusions: These findings provide additional evidence that increases in pulse pressure in mid-life may be
associated with increased risk of AD pathology. This study provides a rationale for using brain imaging to rapidly
evaluate the efficacy of anti-hypertensive medications for the pre-symptomatic treatment of AD.