Spires-Jones TL, Kopeikina KJ, Koffie RM, de Calignon A, Hyman BT.
Are tangles as toxic as they look?.
J Mol Neurosci. 2011 Nov;45(3):438-44.
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In 1999, we published a paper titled "Neurons may live for decades with neurofibrillary tangles." The paper was based on the assumption that if one sees many cells exhibiting a defined morphology (in this case, neurons with both nuclei and NFT), then this must be a morphology that persists. On the other hand, if one rarely sees a defined morphology, then it represents either a fleeting or a rare phenomenon. By quantifying cells in the hippocampus with defined appearances and analyzing these data in the context of the West data on cell numbers (e.g., West et al., 1994), we were able to construct a data-based model that predicted that neurons containing NFT survived for at least two decades, and perhaps longer.
Morsch R, Simon W, Coleman PD.
Neurons may live for decades with neurofibrillary tangles.
J Neuropathol Exp Neurol. 1999 Feb;58(2):188-97.
West MJ, Coleman PD, Flood DG, Troncoso JC.
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease.
Lancet. 1994 Sep 17;344(8925):769-72.