. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. J Cell Biol. 2003 Oct 13;163(1):27-33. PubMed.

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  1. This paper suggests a peptide that may have therapeutic potential. It also suggests the interesting possibility that a ubiquitin-like pathway may participate and promote the toxic effects induced by overexpression of WT or mutant APP.