Cynis H, Scheel E, Saido TC, Schilling S, Demuth HU. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry. 2008 Jul 15;47(28):7405-13. PubMed.
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RIKEN Center for Brain Science
A novel pharmacological target for prevention and treatment of AD. The authors' group previously demonstrated Aβ3(pE)-42 is approximately 250 times more prone to oligomerize than Aβ1-42.
References:
Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Böhm G, Demuth HU. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry. 2006 Oct 17;45(41):12393-9. PubMed.
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