. Amyloid deposition and FDG metabolism in relation to age in APOE4 carriers. Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;

Abstract:

Background: APOE4 carrier status in normal individuals has been associated with both altered glucose metabolism and higher levels of amyloid deposition. Objective: To evaluate the impact of APOE-ε4 carrier status on FDG metabolism considering the effects of PiB retention, cortical thickness and age in cognitively normal (CN) older individuals.

Methods: Forty-three CN subjects, mean age ± SD = 75.6 ± 7.0 (11 ε4 carriers, mean age = 73.4 ± 7.6, and 32 ε4 non-carriers, mean age = 76.4 ± 6.8) underwent PiB (DVR, cerebellar cortex reference region) and FDG (SUV, covariance adjusted for cerebellar cortex SUV) PET and MR imaging; image data was processed using Freesurfer. FDG analyses were performed vertex-wise controlling for precuneus PiB retention, cortical thickness local to each vertex, and age, in order to isolate APOE-ε4 effects on metabolism.

Results: Compared to non-carriers, ε4 carriers had similar precuneus, parietal, frontal and global amyloid deposition, but exhibited hypometabolism in default network areas and hypermetabolism in prefrontal, inferomedial temporal and caudal anterior cingulate regions (cluster-wise corrected pConclusions: These preliminary results in 43 CN subjects suggest that certain frontal and anterior cingulate regions of relative hypermetabolism may mark an important intermediate step along a trajectory of prodromal AD.

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  1. Toronto: HAI Amyloid Imaging Conference Abstracts