. Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology. FASEB J. 2001 Nov;15(13):2433-44. PubMed.

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  1. This paper demostrates that Abeta forms ion channels in vivo, and that channel formation is integral to Abeta's cytotoxic properties. This is the critical extension of the in vitro work on Abeta ion channels to a cellular model. This paper shows that the channel hypothesis of Alzheimer's disease can actually occur in cells. Future work will build on these experiments to show whether channel formation occurs in intact organisms, including humans.

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