Miravalle L, Calero M, Takao M, Roher AE, Ghetti B, Vidal R.
Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques.
Biochemistry. 2005 Aug 16;44(32):10810-21.
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This interesting paper corroborates the new concept that N-terminal truncated Aβ42 species are the seeds of amyloidosis, and a nice target for the vaccination approach.
References:Sergeant N, Bombois S, Ghestem A, Drobecq H, Kostanjevecki V, Missiaen C, Wattez A, David JP, Vanmechelen E, Sergheraert C, Delacourte A. Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach. J Neurochem, 2003, Jun;85(6):1581-91. Abstract