. Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not β-amyloid in cognitively normal older individuals. J Neurosci. 2013 Mar 27;33(13):5553-63. PubMed.

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  1. This work strongly suggests that the molecular mechanism(s) downstream of Aβ deposition need to be identified to fully understand the pathophysiology of AD. Aβ alone is not enough.