Davis DG, Schmitt FA, Wekstein DR, Markesbery WR.
Alzheimer neuropathologic alterations in aged cognitively normal subjects.
J Neuropathol Exp Neurol. 1999 Apr;58(4):376-88.
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'Our study demonstrates that the brains of a large percentage of cognitively normal, relatively well-educated individuals contain numerous degenerative changes and only a small percentage are relatively free of these changes.' The changes referred to are SP and NFT. So, when is AD not AD?