Aβ has superoxide dismutase activity. Might Aβ synthesis be upregulated due to a compensatory reaction to reduced Cu,Zn-SOD activity?
Kang (1) reports that methylglyoxal modifies Cu,Zn-SOD with a resultant loss of enzyme activity and copper leaving the protein.
Is methylglyoxal increased in Down's syndrome as it is in AD, and is it possible that a copper-less Cu,Zn-SOD may signal a necessity in AD and DS for Aβ production?
Do you see cross-linking of Cu,Zn-SOD in AD and DS?
References:
Kang JH.
Modification and inactivation of human Cu,Zn-superoxide dismutase by methylglyoxal.
Mol Cells. 2003 Apr 30;15(2):194-9.
PubMed.
Comments
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Aβ has superoxide dismutase activity. Might Aβ synthesis be upregulated due to a compensatory reaction to reduced Cu,Zn-SOD activity?
Kang (1) reports that methylglyoxal modifies Cu,Zn-SOD with a resultant loss of enzyme activity and copper leaving the protein.
Is methylglyoxal increased in Down's syndrome as it is in AD, and is it possible that a copper-less Cu,Zn-SOD may signal a necessity in AD and DS for Aβ production?
Do you see cross-linking of Cu,Zn-SOD in AD and DS?
References:
Kang JH. Modification and inactivation of human Cu,Zn-superoxide dismutase by methylglyoxal. Mol Cells. 2003 Apr 30;15(2):194-9. PubMed.
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