. Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1. J Neurosci. 2000 Sep 1;20(17):6452-8. PubMed.

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Research Models

  1. APP(V717I) x PS1(A246E)
  2. PS1(A246E)